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Labour and megaprojects: Rethinking productivity and industrial relations policy
02 Jun 2021University of SydneyEllem, B.The coronavirus pandemic has brought industrial relations policy to the centre of attention in many countries. In 2020, the Australian government convened tripartite bodies to address policy in several areas, one being for agreement-making to cover labour on ‘megaprojects’. This initiative revisited criticisms of unions for driving costs up and productivity down on these worksites, the most expen…
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CO2 electrolysis to multicarbon products in strong acid
13 Sep 2021University of SydneyLi, FengwangCarbon dioxide electroreduction (CO2R) is being actively studied as a promising route to convert carbon emissions to valuable chemicals and fuels. However, the fraction of input CO2 that is productively reduced has typically been very low, <2% for multicarbon products; the balance reacts with hydroxide to form carbonate in both alkaline and neutral reactors. Acidic electrolytes would overcome thi…
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Reactor design for electrochemical CO2 conversion toward large-scale applications
13 Sep 2021University of SydneyLi, FengwangThe electrocatalytic carbon dioxide reduction reaction (CO2RR) provides a way to use CO2 to produce valuable fuels and feedstocks powered by renewable electricity. Considerable efforts have been put into the development of catalysts with the aim to achieve high CO2RR performance, i.e., high activity, high product selectivity, and low overpotentials. However, few reports have been focused on the s…
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Activating ATRP Initiators to Incorporate End-Group Modularity into Photo-RAFT Polymerization
14 Oct 2021University of SydneyHakobyan, Karen McErlean, Christopher S.P. Muellner, MarkusHeterogeneous photocatalysis is increasingly used in reversible deactivation radical polymerization (RDRP). In this study, we found that alkyl bromide redox chemistry typically found in atom transfer radical polymerization (ATRP) can be incorporated in concert with dithiocarbonyl disulfide chemistry into the reversible addition–fragmentation chain transfer (RAFT) process via bismuth oxide photoca…
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Molecular Polymer Brushes Made via Ring-Opening Metathesis Polymerization from Cleavable RAFT Macromonomers
14 Oct 2021University of SydneyGegenhuber, Thomas Muellner, MarkusThe use of labile covalent bonds such as oximes and acetals for their application in the synthesis, and controlled triggered deconstruction, of molecular polymer brushes (MPBs) is reported. Macromonomers (MMs) are produced via reversible addition-fragmentation chain transfer (RAFT) polymerization using chain transfer agents (CTAs) featuring customized labile moieties. Ring-opening metathesis poly…
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Stiffness-Dependent Intracellular Location of Cylindrical Polymer Brushes
14 Oct 2021University of SydneyNiederberger, Antoine Pelras, Theophile Salvati Manni, Livia FitzGerald, Paul Warr, Gregory G. Muellner, MarkusCylindrical polymer brushes (CPBs) are macromolecules with nanoparticle proportions. Their modular synthesis enables tailoring of their chemical composition as well as the dialing-up of overall dimensions and physicochemical properties. In this study, two rod-like poly[(ethylene glycol) methyl ether methacrylate] (PEGMA)-based CPBs with varying stiffness but otherwise comparable features and func…
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Molecular stabilization of sub-nanometer Cu clusters for selective CO2 electro-methanation
17 Nov 2021University of SydneyLi, FengwangElectrochemical CO 2 methanation powered by renewable electricity provides a promising approach to utilizing CO 2 in the form of a high-energy-density, clean fuel. Cu nanoclusters have been predicted by theoretical calculations to improve methane selectivity. Direct electrochemical reduction of Cu-based metal-organic frameworks (MOFs) results in large-size Cu nanoparticles which favor multi-carbo…
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Nicotinamide-appended fluorophores as fluorescent redox sensors
03 Dec 2021University of SydneyLeslie, Kathryn G Kolanowski, Jacek L Trinh, Natalie Carrara, Serena Anscomb, Matthew D Yang, Kylie Hogan, Conor F Jolliffe, Katrina A New, Elizabeth JFluorescent sensors have proved invaluable in elucidating the regulation and dysregulation of redox processes in biology, but understanding of the breadth of biological redox reactions requires development of new sensors based on a range of sensing groups with varied reduction potentials. The aim of this work was to investigate the use of nicotinamide as a redox switch when conjugated to two clas…
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An analysis of the experimental and theoretical charge density distributions of the piroxicam-saccharin co-crystal and its constituents
02 May 2016University of SydneyDu, Jonathan J. Váradi, Linda Williams, Peter A. Groundwater, Paul W. Overgaard, Jacob Platts, James A. Hibbs, David E.Experimental and theoretical charge density analyses of piroxicam (1), saccharin (2) and their 1:1 co-crystal complex (3) have been carried out. Electron density distribution (EDD) was determined through the use of high-resolution single crystal X-ray diffraction and the data were modelled using the conventional multipole model of electron density according to the Hansen-Coppens formalism. A meth…
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Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter
21 Jun 2016University of SydneyBrust, Andreas Wang, Ching-I. A. Daly, Norelle L. Kennerly, Joe Sadeghi, Mahsa Christie, Macdonald J. Lewis, Richard J. Mobli, Mehdi Alewood, Paul F.Loopy peptides: Peptide turn mimetics of a clinically relevant norepinephrine reuptake inhibitor were developed employing a high-throughput synthesis approach to generate peptide thioesters, with subsequent cyclization through native chemical ligation. The vicinal disulfide constrained cyclic peptidomimetics (see scheme) show high structural and functional similarity to the parent peptide, though…