English: This study examined the effects of stressors and coping strategies on the well-being of academic staff in an agricultural university in Nigeria. Surveys were administered to 133 faculty members. The stressors identified were heavy workloads, inadequate physical facilities, insufficient resources, poor working conditions, and career advancement expectations; the coping mechanisms employed included active planning, supportseeking and disengagement. Hierarchical moderated regression analysis showed that positive affectivity (PA) was significantly and positively related to job satisfaction and psychological strain. Stressors such as poor working conditions and heavy workloads were significantly and negatively related to job satisfaction and psychological strain, respectively. It is suggested that lessened workloads and improved working conditions might significantly enhance the well-being of faculty members.