The prevalence of playing-related musculoskeletal disorders (PRMD) is high in various countries of the world, but there is a paucity of literature in Africa. The aim of this study was to determine the prevalence of PRMDs among instrumentalists in South Africa, with specific objectives in determining the distribution, symptoms, and pain severity. The self-administered Nordic Musculoskeletal Questionnaire was used to collect information from
the participants regarding the lifetime and current prevalence and the distribution of PRMD symptoms. A visual analog scale was used to collect information on the severity of pain, while the questionnaire designed by Blackie, Stone, and Tiernan (1999) was used to collect information on the symptoms of the PRMDs. Twenty participants took part in this study, and the respondents reported a lifetime prevalence (over a period of 12 months) of PRMDs as 14 out of 17 and the current prevalence (in the last 7 days) as 4. Pain severity was mostly mild, and the most affected region was in the upper extremities, with the shoulders being the most affected. Tightening and soreness were the most reported symptom of PRMDs. The prevalence of PRMDs among this population was high, although severity was mild, with the upper extremities being the most affected area.