Background: It is well documented that there is some correlation between poor oral health in the form of
periodontal disease and coronary heart disease (CHD). It is unclear whether this correlation is due to a causal
relationship or shared underlying disorder such as inflammation. A suitable integrated model of the CHD
pathogenetic pathways relevant to periodontal disease may help to elucidate the association. Such a model is
currently not available in literature.
Methods: A previously developed integrated model of CHD was used to investigate potential pathogenetic
pathways linking periodontal disease to CHD biomarkers.
Results: The integrated model was created to provide insight into possible higher-order biological interactions
underlying CHD and periodontal disease. In order to simplify these interactions a novel ‘connection graph’ was
developed. It quantitatively illustrates the relationship between periodontal disease and various serological
biomarkers of CHD. The pathogenesis of periodontitis shows various possible pathways which could link
periodontitis to CHD pathogenesis.
Conclusion: An integrated model of CHD was developed which provides a summary of the potential CHD effects
of periodontal disease. Further research must refine and validate the model