(1) It has been shown that therapeutic doses of sulphanilamide depress
cellulose digestion and appetite in ruminants.
(2) The fermentation of sugar and gas formation are also suppressed but only
by higher concentrations.
(3) The absorption of sulphanilamide after intra-ruminal dosing is very slow
and effective blood concentrations are not attained with recognised therapeutic
(4) The absorption of sulphanilamide is further retarded by paralysis of the
rumen induced by atropin.
(5) These findings raise the question as to the advisability of dosing sulphonamides
to ruminants in view of their deleterious effects on cellulose digestion
and appetite and the low blood concentration of the drug achieved by dosing.