The anti-diabetic properties of syzygium jambolanum : a systematic review

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Peer-Reviewed Research
  • SDG 3
  • Abstract:

    Abstract: Throughout the world, diabetes mellitus is a common and serious metabolic disorder that is characterized by elevated plasma glucose levels due to an impairment in the action or secretion of insulin. Chronic impairment in plasma glucose levels eventually results in damage to the micro-vascular circulation, especially the eyes, kidneys, nerves and blood vessels. Prolonged hyperglycaemia will eventually result in life threatening complications (Peer et al., 2014). Chronic non-communicable diseases such as cardiovascular disease, cancer, chronic respiratory disease and diabetes have become a great contributor to the mortality rate world wide. Despite attempts to prevent and control the epidemic with various interventions and strategies, the number of people suffering from non-communicable diseases are increasing at an alarming rate in South Africa and around the world (Solomons et al., 2017). Prominent causes of these non-communicable diseases can be prevented, however, urgent interventions are needed along with efficient strategies to deal with the associated risk factors of these diseases (Boutayeb and Boutayeb, 2005). There are several drugs that are effective in lowering hyperglycaemia in patients with type 2 diabetes mellitus, however, these drugs have a high incidence of side effects such as gastrointestinal complications, thus leading to an increasing number of people seeking alternative therapy with fewer adverse effects (Colledge et al., 2010). Several medicinal plants have been identified to lower blood glucose levels and to treat the symptoms and complications of diabetes mellitus. Syzygium jambolanum is a commonly used medicinal plant for the treatment of various disorders, especially diabetes mellitus and its complications. Many clinical and experimental studies have shown that different parts of the Syzygium jambolanum plant are known to possess a wide range of medicinal properties, effective in lowering blood glucose levels as well as preventing the complications of hyperglycaemia (Chagas et al. 2015). Syzygium jambolanum has been studied extensively for more than a century and promising results in both animal and human studies for its ability to lower blood glucose levels have been reported (Elavarasi et al., 2013). However, very few studies have been conducted in humans (Helmstadter, 2008). This systematic review was based on the available literature accessed from the University of Johannesburg electronic database. The Cochrane Collaboration guidelines were followed to identify and analyse any available literature pertaining to the anti-diabetic properties of the different parts of Syzygium jambolanum to...