The most significant pathological changes in the central nervous system of 27
cases of heartwater are described. In addition to leucostasis and cell infiltration in the
perivascular and subarachnoid spaces described previously, the following changes
Swollen axis-cylinders, microcavitation and focal necrosis of the cerebellar
cortex; degenerative and necrotic changes in the neuroglia accompanied by the
formation of P.A.S. positive intracytoplasmic granules and globules; the accumulation
of P.A.S. positive globules in the V.R. spaces; choriomeningeal oedema and
fibrinous choriomeningitis; haemorrhages, oedema and vascular changes.
Evidence is submitted in favour of the perivascular globules being proteinaceous
and of glial origin.