A 25-year-old female was referred to the Haematology
Unit at Tygerberg Hospital for further management of a
rapidly expanding and large submandibular mass which
on fine needle aspiration was suggestive of lymphoma . Five months earlier she had been diagnosed
with pulmonary tuberculosis and was confirmed to be
HIV positive with a CD4 count of 17. She was placed on
anti-retroviral (ARV) and antituberculous therapy (the ARV
therapy included efavirenz, emtricitabine and tenofivir).
Her CD4 count, at the time of the current consultation,
was 204 and the viral load was suppressed. Lumbar
puncture was normal. Significant clinical findings were
a large right submandibular mass and right cervical and
axillary lymphadenopathy. The submandibular mass was
removed and submitted for histological examination.