Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress,inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats.

12 Apr 2019

Vindoline, an indole alkaloid present in the leaves of Catharanthus roseus plant, has been recently reported to have insulotropic effects. This present study evaluated the possible hepatoprotective effects of vindoline in a type 2 diabetes mellitus rat model. Diabetes mellitus was induced by exposing rats to 10% fructose water for two weeks followed by a single intraperitoneal injection of 40?mg/kg body weight of streptozotocin (STZ). Rats were randomly divided into six groups (n?=?8) and treated daily for 6 weeks with the vehicle via oral gavage, vindoline (20?mg/kg) or glibenclamide (5?mg/kg). Weekly fasting blood glucose (FBG) levels and body weight were measured and recorded. Administration of vindoline significantly (p?