Toxicity and carcinogenicity of the fusanum monilzforine metabolite, fumonisin B1, in rats.

29 Mar 2017

A semi-purified corn-based diet containing 50 mg/kg of pure (not <90%) fumonlsin B1 (FB1), isolated from culture material of Fusarusm monthforme strain MRC 826, was fed to a group of 25 rats over a period of 26 months. A control group of 25 rats received the same diet without FB1 Five rats from each group were killed at 6, 12, 20 and 26 months. The liver was the main target organ in the FB1-rats and the hepatic pathological changes were identical to those previously reported in rats fed culture material of F.moniliforme MRC 826. All FB1-treated rats that died or were killed from 18 months onwards suffered from a micro-and macronodular cirrhosis and had large expansile nodules of cholangiofibrosis at the hilus of the liver. Ten out of 15 FB1-trested rats (66%) that were killed and/or died between 18 and 26 months developed primary hepatocellular carcinoma. Metastases to the heart, lungs or kidneys were present in four of the rats with hepatocellular carcinoma. No neoplastic changes were observed in any of the control rats. Chronic interstitial nephritis was present in the kidneys of FB1-trested rats killed after 26 months. No lesions were observed in the esophagus, heart or forestomach of FB1-trested rats and this is contrary to previous findings when culture material of the fungus was fed to rats. It is conduded that FB1-trested is responsible for the hepatocarcinogenic and the hepatotoxic but not all the other toxic effects of culture material of F.moniliforme MRC 826 in rats.