The evolving role of multiparametric MRI in prostate cancer work-up01 May 2018
Prostate cancer is the leading cause of cancer death in men after skin cancer, with an incidence expected to double by 2030 mainly due to the ageing population. However, many more men die with prostate cancer rather than from the disease, highlighting the indolent nature of many tumours. Recently, multiparametric MRI has revolutionised the work-up of prostate cancer, becoming a routine part of clinical practice and migrating earlier in the diagnostic pathway. However, the technique remains challenging, with patient-related factors, intrinsic insensitivity of MRI, protocol differences, and radiologist experienced all combining to limit its overall accuracy. Anatomical T2-weighted imaging is limited by the non-specific nature of its findings and improvements have mainly been driven by the addition of functional sequences such as diffusion-weighted imaging, dynamic contrast-enhanced MRI and spectroscopy. In the absence of validated circulating biomarkers, only functional imaging currently offers the potential for further improvements in lesion detection and characterisation, with the additional advantages of providing whole gland coverage of the prostate and being non-invasive. An overview of the evolving role of prostate multiparametric MRI is provided, along with its strengths and weaknesses and an exploration of how it can help overcome limitations in the traditional work-up of patients.