The Dutch resolution method: attempted enhanced selectivity of 2-Butylamine with mixed diol hosts

19 Nov 2020

The Dutch resolution method was employed to resolve 2-butylamine. Four similar diol host compounds were utilized singly and in combination to obtain inclusion compounds that displayed partial enantiomeric selectivity. However, the combination of any pair of host compounds did not significantly improve the enantiomeric excess of the 2-butylamine over that given by single host compounds. We attribute the results to the constant packing patterns of the structures.