Inclusion compounds of hydroxynaphthoic acids: co-crystal vs. salt formation10 Nov 2020
6-Hydroxy-2-naphthoic acid, H1, forms solvates with 1,4-dioxane (DIOX) and dimethyl sulfoxide (DMSO), and their structures are stabilized by host?host and host?guest hydrogen bonds. H1 forms a hydrated salt with 1,4-diazabicyclo[2.2.2]octane, DABCO, with stoichiometry 2H1$2DABCO$3H2O. Two other naphthoic acid isomers, 1-hydroxy-2-naphthoic acid, H2, and 3-hydroxy-2-naphthoic acid, H3, form salts with DABCO with host : guest ratios of 2 : 1. The kinetics of thermal decomposition of the H1$?DIOX compound yields an activation energy of 60 kJ mol1 for the desolvation reaction.