Biosynthesis of landomycin E deoxysugar part in Streptomyces globisporus 1912: sequencing and analysis of lndZ1 and lndZ3 genes

10 Sep 2019

DNA fragment of landomycin E biosynthesis gene cluster 1.5 kb in size has been completely sequenced and two open reading frames were identified. Gene lndZ1 resembles NDP-hexose-3,5-epimerase and lndZ3 is similar to NDP-hexose-4-ketoreductases. LndZ1 and LndZ3 proteins are suggested to accomplish two last catalytic steps towards deoxysugar L-rhodinose present in landomycin E carbohydrate moiety